Stay away from using Promethazine HCl and Codeine Phosphate Oral Remedy in adolescents 12 to eighteen a long time of age who produce other hazard aspects which could improve their sensitivity to the respiratory depressant consequences of codeine Except the advantages outweigh the threats.
The respiratory melancholy involves a discount inside the responsiveness in the Mind stem respiratory centers to both of those improves in carbon dioxide tension and to electrical stimulation.
Codeine: A analyze in rats and rabbits described no teratogenic impact of codeine administered in the course of the duration of organogenesis in doses ranging from five to one hundred twenty mg/kg. From the rat, doses at the 120-mg/kg degree, in the harmful assortment for that Grownup animal, had been related to an increase in embryo resorption at some time of implantation.
To help prevent withdrawal, your doctor may perhaps reduce your dose slowly and gradually. Withdrawal is more possible When you've got utilised this medication for some time (quite a lot of months) or in higher doses. Notify your physician or pharmacist instantly if you have withdrawal.
The respiratory-depressant consequences of narcotic analgesics as well as their potential to elevate cerebrospinal fluid pressure could possibly be markedly exaggerated inside the existence of head injuries, intracranial lesions or maybe a pre-present increase in intracranial strain.
In sufferers getting MAO inhibitors, an Original smaller test dose is sensible to allow observation of any too much narcotic effects or MAOI conversation.
Avoid the use of Promethazine HCl and Codeine Phosphate Oral Promethazine codeine syrup Alternative in adolescents twelve to eighteen many years of age who have other threat things which could improve their sensitivity to the respiratory depressant effects of codeine. Danger components incorporate circumstances connected with hypoventilation, which include postoperative standing, obstructive sleep apnea, being overweight, serious pulmonary illness, neuromuscular sickness, and concomitant usage of other medications that lead to respiratory melancholy.
This rapid conversion brings about larger than predicted serum morphine concentrations. Even at labeled dosage regimens, people who are extremely-speedy metabolizers may encounter overdose indicators for example Severe sleepiness, confusion, or shallow breathing.
Overdose of codeine in Grownups has long been connected to lethal respiratory melancholy, and the use of codeine in youngsters youthful than 12 many years of age has become connected with lethal respiratory melancholy when employed as recommended [see Warnings and Safety measures (5.
Animal reproduction scientific studies haven't been executed With all the drug combination-promethazine and codeine. It is far from recognised no matter if this drug combination may cause fetal damage when administered to your pregnant woman or can have an effect on reproduction potential.
Ahead of getting this medication, notify your medical doctor or pharmacist Should you be allergic to any of its elements; or to opioid pain relievers (like morphine); or In case you have another allergic reactions.
Tend not to flush medications down the rest room or pour them right into a drain Until instructed to take action. Appropriately discard this product when it can be expired or no more required. Talk to your pharmacist or local squander disposal business.
Published experiments with codeine have documented inconsistent conclusions and also have critical methodological restrictions (see Info). You will discover reports of respiratory melancholy when codeine is utilized all through labor and shipping and delivery (see Scientific Criteria).
The effect of promethazine and/or codeine within the afterwards advancement and growth with the new child is unidentified.